A Non-Surgical Alternative
for Peyronie’s Disease
Regenerative PRP therapy combined with physician-guided plaque needling — targeting penile curvature, pain, and erectile function without surgery, implants, or synthetic fillers.
“Most urologists treat Peyronie’s with Xiaflex injections or surgery. We offer an advanced regenerative option that has helped many of our patients avoid both.”
Peyronie’s disease is a connective tissue disorder characterized by the development of fibrous scar tissue (plaque) within the penis. This plaque can cause curvature during erection, penile pain, loss of length or girth, and erectile dysfunction.
For many men, Peyronie’s doesn’t resolve on its own — and traditional treatments like Xiaflex injections or surgical plication aren’t always appealing or available. At Prestige Medical Group, Dr. Gabal offers a regenerative, non-surgical alternative: PRP therapy combined with physician-guided plaque needling.
This treatment approach requires specialized training in regenerative urology and isn’t widely available — but for the right candidates, it offers a non-surgical pathway that preserves natural anatomy and uses the body’s own healing factors.
Understanding Peyronie’s Disease
Peyronie’s affects the tunica albuginea — the elastic sheath surrounding the erectile chambers — restricting normal expansion during erections.
Common Symptoms
Some cases stabilize without treatment, but many men experience progressive worsening that significantly impacts intimacy, confidence, and quality of life. Early evaluation and intervention often lead to better outcomes.
Dr. Gabal on Our PRP Protocol
In this video, Dr. Gabal explains our PRP regenerative protocol — the same foundational technique used in the P-Long program. For Peyronie’s disease, this proven PRP approach is precisely adapted by targeting injections directly at the plaque, often combined with plaque needling to maximize tissue remodeling.
Dr. Gabal demonstrates our regenerative PRP technique in the context of the P-Long protocol. The identical PRP methodology is used — and precisely targeted — in our Peyronie’s treatment.
A Two-Step Regenerative Protocol
Plaque needling disrupts the scar tissue. PRP delivers growth factors to help the body remodel it. Together, they work with your body’s natural healing processes.
A physician-guided technique that creates micro-channels through the plaque to disrupt dense fibrotic tissue. This triggers a localized healing response and allows for better penetration of regenerative therapy. Performed under topical numbing in the office.
Platelet-rich plasma prepared from a small sample of your own blood is injected into and around the plaque. PRP contains concentrated growth factors that support collagen remodeling, improved blood flow, and tissue regeneration — potentially softening the plaque and improving flexibility over time.
What the Research Suggests
Clinical studies and pilot trials have reported a favorable safety profile with possible improvements in curvature, erectile function, and reduced plaque density in some patients. The published research base is still growing — and this approach is appropriately considered investigational while clinicians continue to refine protocols.
At Prestige Medical Group, we’ve seen excellent results in many of our patients, which is why we’ve continued to invest in this treatment despite most urologists not offering it. Results vary based on severity, phase of disease, and individual response.
Combining with ShockWave Therapy
In select cases, Dr. Gabal may recommend adding ShockWave Therapy to your protocol. Low-intensity shockwaves can further support tissue remodeling and improved blood flow — which may enhance results from PRP and plaque needling, particularly for patients also experiencing erectile dysfunction.
The right combination is determined at your consultation based on your specific anatomy, severity, and treatment goals.
Who May Be a Good Candidate?
This regenerative approach may be well-suited for:
- Men with stable or early-stage Peyronie’s disease
- Men seeking a non-surgical alternative to plication or implants
- Men who have not had success with other treatments (Xiaflex, oral medication)
- Men with persistent curvature, plaque, or ED symptoms
- Men who want to preserve natural anatomy and avoid synthetic fillers
- Men also experiencing erectile dysfunction who may benefit from combined treatment
A consultation and ultrasound evaluation are required to determine candidacy and develop an individualized treatment plan.
Potential Benefits
- Minimally invasive — in-office procedure with topical numbing
- Uses your body’s own healing factors — PRP from your own blood
- No synthetic fillers or foreign substances
- Little to no downtime — most patients return to normal activities the same day
- Can be combined with penile modeling or ShockWave therapy for enhanced results
- Avoids surgery while still targeting the underlying plaque
- Preserves natural anatomy — no implants or incisions
Frequently Asked Questions
Is PRP with plaque needling painful?
How many treatments will I need?
Why don’t most urologists offer this?
Is this treatment FDA-approved?
Does this really work?
Is there downtime?
Can this be combined with other treatments?
How much does it cost?
Ready to Explore a Non-Surgical Option?
Schedule a confidential consultation with Dr. Lamia Gabal to discuss whether PRP with plaque needling may be right for you. We’ll perform an ultrasound evaluation, review all available treatment options — including FDA-approved alternatives — and develop a personalized plan.