What is Retatrutide?

Retatrutide is an investigational, next-generation weight-loss peptide being studied for its ability to support appetite control, insulin sensitivity, and energy balance. Unlike traditional GLP-1 medications, Retatrutide works on multiple metabolic pathways at the same time.

How is Retatrutide different from Semaglutide or Tirzepatide?

  • Semaglutide primarily focuses on appetite suppression
  • Tirzepatide supports appetite control and insulin response
  • Retatrutide targets appetite regulation, insulin signaling, and energy expenditure

Because of this broader approach, some patients consider Retatrutide after plateauing on other weight-loss medications.

Can Retatrutide make me feel more tired?

Yes, some patients experience temporary fatigue, especially during the first few weeks or after dose increases. Retatrutide increases how much energy the body uses, while also reducing calorie intake. This combination can feel tiring at first but typically improves as the body adjusts.

Can Retatrutide make me feel more hungry?

In some patients, mild hunger may occur early on. This does not mean the medication isn’t working. Retatrutide’s effect on energy expenditure can temporarily increase the body’s demand for fuel before appetite regulation stabilizes.

How long do these adjustment symptoms last?

Most patients notice improvement within 1–3 weeks as the body adapts. Starting at a lower dose and increasing gradually helps minimize side effects.

What can I do to feel better while adjusting?

Patients often feel best when they:

  • Prioritize adequate protein intake
  • Stay well hydrated
  • Use electrolytes if recommended by their provider
  • Avoid extreme calorie restriction early on
  • Follow the prescribed titration schedule

Is Retatrutide FDA-approved?

No. Retatrutide is currently considered investigational and is not FDA-approved for weight loss. It is offered under medical supervision after a comprehensive evaluation.

Who may be a good candidate for Retatrutide?

Retatrutide may be considered for patients who:

  • Have tried Semaglutide or Tirzepatide with limited results
  • Have reached a weight-loss plateau
  • Are seeking a more advanced metabolic approach
  • Are comfortable using an investigational therapy under medical guidance

How is Retatrutide taken?

Retatrutide is administered as a weekly injection. Dosage is individualized and increased gradually based on tolerance and response.

When should I contact the clinic?

You should contact us if you experience:

  • Persistent nausea or vomiting
  • Severe fatigue that does not improve
  • Dizziness or dehydration
  • Any symptoms that concern you

Our team is here to support you throughout your treatment.

Interested in learning more?

Schedule a consultation with our medical team to determine whether Retatrutide may be right for you.